Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: Reversing mitochondrial dysfunction and upregulating glyoxalase 1

Diabetic retinopathy (DR) is a major cause of blindness in adult, and the accumulation of advanced glycation end products (AGEs) is a major pathologic event in DR. Methylglyoxal (MGO), a highly reactive dicarbonyl compound, is a precursor of AGEs. Although the therapeutic potential of metformin for...

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Detalles Bibliográficos
Autores principales: Sekar, Ponarulselvam, Hsiao, George, Hsu, Shu-Hao, Huang, Duen-Yi, Lin, Wan-Wan, Chan, Chi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363482/
https://www.ncbi.nlm.nih.gov/pubmed/37348156
http://dx.doi.org/10.1016/j.redox.2023.102786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363482/
https://www.ncbi.nlm.nih.gov/pubmed/37348156
http://dx.doi.org/10.1016/j.redox.2023.102786

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