Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated dexamphetamine-induced improvements of mood and (visuo)motor performance in a huma...

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Detalles Bibliográficos
Autores principales: Recourt, Kasper, de Boer, Peter, van der Ark, Peter, Benes, Heike, van Gerven, Joop M. A., Ceusters, Marc, van Nueten, Luc, Drevets, Wayne C., Bhatacharya, Anindya, Browning, Michael, Jacobs, Gabriel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363543/
https://www.ncbi.nlm.nih.gov/pubmed/37482560
http://dx.doi.org/10.1038/s41398-023-02557-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363543/
https://www.ncbi.nlm.nih.gov/pubmed/37482560
http://dx.doi.org/10.1038/s41398-023-02557-5

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