Cargando…

FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis

Uveitis, a vision-threatening inflammatory disease worldwide, is closely related to resident microglia. Retinal microglia are the main immune effector cells with strong plasticity, but their role in uveitis remains unclear. N6-methyladenosine (m(6)A) modification has been proven to be involved in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Siyuan, Li, Wanqian, Wang, Guoqing, Wang, Xiaotang, Fan, Wei, Zhang, Zhi, Li, Na, Hou, Shengping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2022
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363593/ https://www.ncbi.nlm.nih.gov/pubmed/37492748 http://dx.doi.org/10.1016/j.gendis.2022.09.008

Ejemplares similares

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization
por: Shu, Nan, et al.
Publicado: (2023)

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization
por: Wang, Guoqing, et al.
Publicado: (2022)

Global lactylome reveals lactylation-dependent mechanisms underlying T(H)17 differentiation in experimental autoimmune uveitis
por: Fan, Wei, et al.
Publicado: (2023)

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2
por: Wang, Xiaotang, et al.
Publicado: (2023)

TLR2 and TLR4 Signaling Pathways and Gastric Cancer: Insights from Transcriptomics and Sample Validation
por: Zargari, Saeed, et al.
Publicado: (2022)

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4
por: Shen, Xiujin, et al.
Publicado: (2020)

Expression of TLR4-MyD88 and NF-κB in the Iris during Endotoxin-Induced Uveitis
por: Li, Shang, et al.
Publicado: (2010)

Modulation of TLR4/NFκB Pathways in Autoimmune Myocarditis
por: Interdonato, Livia, et al.
Publicado: (2023)

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia
por: Zhao, Chenyang, et al.
Publicado: (2022)

Polyguanine alleviated autoimmune hepatitis through regulation of macrophage receptor with collagenous structure and TLR4‐TRIF‐NF‐κB signalling
por: Cai, Tingchen, et al.
Publicado: (2022)

Oxycodone Alleviates Endometrial Injury via the TLR4/NF-κB Pathway
por: Zhu, Aibing, et al.
Publicado: (2022)

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway
por: Zusso, Morena, et al.
Publicado: (2019)

Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation
por: Kim, Shin Young, et al.
Publicado: (2019)

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice
por: Niu, Xinyu, et al.
Publicado: (2023)

Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia
por: Cui, Yu, et al.
Publicado: (2022)

Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway
por: Liang, Xuemei, et al.
Publicado: (2023)

HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy
por: Shi, Yunbo, et al.
Publicado: (2018)

Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice
por: Hsu, Sheng-Min, et al.
Publicado: (2020)

SOCS2 overexpression alleviates diabetic nephropathy in rats by inhibiting the TLR4/NF-κB pathway
por: Yang, Suxia, et al.
Publicado: (2017)

2-Methoxyestradiol Alleviates Experimental Autoimmune Uveitis by Inhibiting Lymphocytes Proliferation and T Cell Differentiation
por: Xu, Linxinyu, et al.
Publicado: (2016)

Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis
por: Lo, Sheng-Min, et al.
Publicado: (2022)

Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk
por: Lv, Jianlu, et al.
Publicado: (2022)

Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB Pathway
por: Cheng, Ping, et al.
Publicado: (2017)

Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR 4/NF-κB pathway and protecting the intestinal barrier
por: Yan, Bo, et al.
Publicado: (2022)

A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway
por: Kang, Yongbo, et al.
Publicado: (2023)

Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-κB Pathway
por: Zhang, Jiawen, et al.
Publicado: (2021)

Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation
por: Derkow, Katja, et al.
Publicado: (2015)

Osthole Alleviates D-Galactose-Induced Liver Injury In Vivo via the TLR4/MAPK/NF-κB Pathways
por: Ma, Zhe, et al.
Publicado: (2023)

Tacrolimus alleviates LPS‐induced AKI by inhibiting TLR4/MyD88/NF‐κB signalling in mice
por: Hu, Xueqing, et al.
Publicado: (2021)

pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain
por: Kim, Sehwan, et al.
Publicado: (2023)

Dexmedetomidine alleviates airway hyperresponsiveness and allergic airway inflammation through the TLR4/NF-κB signaling pathway in mice
por: Xiao, Shilin, et al.
Publicado: (2022)

Microbiome and Autoimmune Uveitis
por: Horai, Reiko, et al.
Publicado: (2019)

Cryptotanshinone alleviates polycystic ovary syndrome in rats by regulating the HMGB1/TLR4/NF-κB signaling pathway
por: Yang, Yijiao, et al.
Publicado: (2020)

Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis
por: Qu, Yifan, et al.
Publicado: (2021)

Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling
por: Zhang, Chengfei, et al.
Publicado: (2023)

Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway
por: Li, Yaqian, et al.
Publicado: (2022)

SOX2‐positive retinal stem cells are identified in adult human pars plicata by single‐cell transcriptomic analyses
por: Wang, Xiaotang, et al.
Publicado: (2022)

Calycosin attenuates the inflammatory damage of microglia induced by oxygen and glucose deprivation through the HMGB1/TLR4/NF-κB signaling pathway: Calycosin attenuates OGD/R damage in microglia
por: Li, Xiang, et al.
Publicado: (2023)

Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway
por: Zhou, Ping, et al.
Publicado: (2022)

The Role of Microglia/Macrophages Activation and TLR4/NF-κB/MAPK Pathway in Distraction Spinal Cord Injury-Induced Inflammation
por: Liang, Weishi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2p8m7k0ftinepjhs78c6sqvd8r