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Triad3A involved in the regulation of endotoxin tolerance and mycobactericidal activity through the NFκB‐nitric oxide pathway

INTRODUCTION: Sepsis is characterized by an endotoxin tolerance phenotype that occurs in the stage of infection. Persistent bacterial infection can lead to immune cell exhaustion. Triad3A, an E3 ubiquitin ligase, negatively regulates its activation by TLR4. However, the effect of Triad3A on endotoxi...

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Detalles Bibliográficos
Autores principales: Qin, Yongwei, Chen, Jinliang, Xu, Kuang, Lu, Yang, Xu, Feifan, Shi, Jiahai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363814/
https://www.ncbi.nlm.nih.gov/pubmed/37506157
http://dx.doi.org/10.1002/iid3.925