Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker

Antibody-Drug Conjugates (ADCs) and Small Molecule-Drug Conjugates (SMDCs) represent successful examples of targeted drug-delivery technologies for overcoming unwanted side effects of conventional chemotherapy in cancer treatment. In both strategies, a cytotoxic payload is connected to the tumor hom...

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Detalles Bibliográficos
Autores principales: Zambra, Marco, Ranđelović, Ivan, Talarico, Francesco, Borbély, Adina, Svajda, Laura, Tóvári, József, Mező, Gábor, Bodero, Lizeth, Colombo, Sveva, Arrigoni, Federico, Fasola, Elettra, Gazzola, Silvia, Piarulli, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363981/
https://www.ncbi.nlm.nih.gov/pubmed/37492088
http://dx.doi.org/10.3389/fphar.2023.1215694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363981/
https://www.ncbi.nlm.nih.gov/pubmed/37492088
http://dx.doi.org/10.3389/fphar.2023.1215694

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