Evaluation of chronic drug-induced electrophysiological and cytotoxic effects using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

Introduction: Cardiotoxicity is one of the leading causes of compound attrition during drug development. Most in vitro screening platforms aim at detecting acute cardio-electrophysiological changes and drug-induced chronic functional alterations are often not studied in the early stage of drug devel...

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Detalles Bibliográficos
Autores principales: Altrocchi, C., Van Ammel, K., Steemans, M., Kreir, M., Tekle, F., Teisman, A., Gallacher, D. J., Lu, H. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364322/
https://www.ncbi.nlm.nih.gov/pubmed/37492082
http://dx.doi.org/10.3389/fphar.2023.1229960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364322/
https://www.ncbi.nlm.nih.gov/pubmed/37492082
http://dx.doi.org/10.3389/fphar.2023.1229960

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