Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion

A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from Bacteroides fragilis was used successfully to remove type B blood group antigens enzymatically from human kidneys using ex vivo normo...

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Detalles Bibliográficos
Autores principales: MacMillan, Serena, Hosgood, Sarah A, Nicholson, Michael L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364487/
https://www.ncbi.nlm.nih.gov/pubmed/36038141
http://dx.doi.org/10.1093/bjs/znac293
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author MacMillan, Serena
Hosgood, Sarah A
Nicholson, Michael L
author_facet MacMillan, Serena
Hosgood, Sarah A
Nicholson, Michael L
author_sort MacMillan, Serena
collection PubMed
description A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from Bacteroides fragilis was used successfully to remove type B blood group antigens enzymatically from human kidneys using ex vivo normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation.
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spelling pubmed-103644872023-07-31 Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion MacMillan, Serena Hosgood, Sarah A Nicholson, Michael L Br J Surg Short Report A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from Bacteroides fragilis was used successfully to remove type B blood group antigens enzymatically from human kidneys using ex vivo normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation. Oxford University Press 2022-08-30 /pmc/articles/PMC10364487/ /pubmed/36038141 http://dx.doi.org/10.1093/bjs/znac293 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the BJS Society Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
MacMillan, Serena
Hosgood, Sarah A
Nicholson, Michael L
Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion
title Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion
title_full Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion
title_fullStr Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion
title_full_unstemmed Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion
title_short Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion
title_sort enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364487/
https://www.ncbi.nlm.nih.gov/pubmed/36038141
http://dx.doi.org/10.1093/bjs/znac293
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