Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control

Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the underlying mechanisms remain unknown. Here, we show in Caenorhabditis elegans and mammalian cells that readthrough proteins are t...

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Detalles Bibliográficos
Autores principales: Müller, Martin B.D., Kasturi, Prasad, Jayaraj, Gopal G., Hartl, F. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364623/
https://www.ncbi.nlm.nih.gov/pubmed/37339632
http://dx.doi.org/10.1016/j.cell.2023.05.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364623/
https://www.ncbi.nlm.nih.gov/pubmed/37339632
http://dx.doi.org/10.1016/j.cell.2023.05.035

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