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Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the underlying mechanisms remain unknown. Here, we show in Caenorhabditis elegans and mammalian cells that readthrough proteins are t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364623/ https://www.ncbi.nlm.nih.gov/pubmed/37339632 http://dx.doi.org/10.1016/j.cell.2023.05.035 |