AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model

PURPOSE: Complement dysregulation in the eye has been implicated in the pathogenesis of age-related macular degeneration (AMD), and genetic variants of complement factor H (CFH) are strongly associated with AMD risk. We therefore aimed to untangle the role of CFH and its splice variant, factor H-lik...

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Detalles Bibliográficos
Autores principales: Grigsby, Daniel, Klingeborn, Mikael, Kelly, Una, Chew, Lindsey A., Asokan, Aravind, Devlin, Garth, Smith, Sharon, Keyes, Lisa, Timmers, Adrian, Scaria, Abraham, Bowes Rickman, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365136/
https://www.ncbi.nlm.nih.gov/pubmed/37471073
http://dx.doi.org/10.1167/iovs.64.10.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365136/
https://www.ncbi.nlm.nih.gov/pubmed/37471073
http://dx.doi.org/10.1167/iovs.64.10.25

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