Efficient production of bispecific antibodies—optimization of transfection strategy leads to high-level stable cell line generation of a Fabs-in-tandem immunoglobin

Bispecific antibodies (bsAbs) are often composed of more than two component chains, such as Fabs-in-tandem immunoglobin (FIT-Ig) comprising three different component chains, which bring challenges for generating a high proportion of the correctly assembled bsAbs in a stable cell line. During the CHO...

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Detalles Bibliográficos
Autores principales: Gong, Shiyong, Wu, Chengbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Bispecific Antibody CMC
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365153/
https://www.ncbi.nlm.nih.gov/pubmed/37492586
http://dx.doi.org/10.1093/abt/tbad013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365153/
https://www.ncbi.nlm.nih.gov/pubmed/37492586
http://dx.doi.org/10.1093/abt/tbad013

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