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Participation bias in the UK Biobank distorts genetic associations and downstream analyses

While volunteer-based studies such as the UK Biobank have become the cornerstone of genetic epidemiology, the participating individuals are rarely representative of their target population. To evaluate the impact of selective participation, here we derived UK Biobank participation probabilities on t...

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Detalles Bibliográficos
Autores principales: Schoeler, Tabea, Speed, Doug, Porcu, Eleonora, Pirastu, Nicola, Pingault, Jean-Baptiste, Kutalik, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10365993/
https://www.ncbi.nlm.nih.gov/pubmed/37106081
http://dx.doi.org/10.1038/s41562-023-01579-9