Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells

Thiopurines, such as 6-mercaptopurine (6-MP), are widely used as cytotoxic agents and immunosuppressants for leukemia and autoimmune or inflammatory diseases. A nonsynonymous single nucleotide polymorphism (p.Arg139Cys; R139C) of the nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene...

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Detalles Bibliográficos
Autores principales: Yamashita, Noriaki, Kawahara, Masahiro, Imai, Takayuki, Tatsumi, Goichi, Asai-Nishishita, Ai, Andoh, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366091/
https://www.ncbi.nlm.nih.gov/pubmed/37488179
http://dx.doi.org/10.1038/s41598-023-38952-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366091/
https://www.ncbi.nlm.nih.gov/pubmed/37488179
http://dx.doi.org/10.1038/s41598-023-38952-7

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