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Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells

Thiopurines, such as 6-mercaptopurine (6-MP), are widely used as cytotoxic agents and immunosuppressants for leukemia and autoimmune or inflammatory diseases. A nonsynonymous single nucleotide polymorphism (p.Arg139Cys; R139C) of the nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene...

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Detalles Bibliográficos
Autores principales:	Yamashita, Noriaki, Kawahara, Masahiro, Imai, Takayuki, Tatsumi, Goichi, Asai-Nishishita, Ai, Andoh, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366091/ https://www.ncbi.nlm.nih.gov/pubmed/37488179 http://dx.doi.org/10.1038/s41598-023-38952-7

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