A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models

Opioid use disorders (OUD) and overdose are public health threats worldwide. Widespread access to highly potent illicit synthetic opioids such as fentanyl is driving the recent rise in fatal overdoses. Vaccines containing fentanyl-based haptens conjugated to immunogenic carrier proteins offer a long...

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Detalles Bibliográficos
Autores principales: Crouse, Bethany, Miller, Shannon M., Muelken, Peter, Hicks, Linda, Vigliaturo, Jennifer R., Marker, Cheryl L., Guedes, Alonso G. P., Pentel, Paul R., Evans, Jay T., LeSage, Mark G., Pravetoni, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366150/
https://www.ncbi.nlm.nih.gov/pubmed/37488109
http://dx.doi.org/10.1038/s41541-023-00697-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366150/
https://www.ncbi.nlm.nih.gov/pubmed/37488109
http://dx.doi.org/10.1038/s41541-023-00697-9

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