GANT-61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma

Chondrosarcoma is ineffective for conventional radiotherapy and chemotherapy with a poor prognosis. Hedgehog (Hh) signal pathway plays a crucial role in tumor growth and progression, which is constitutive activated in chondrosarcoma. GLI transcription factors as targets for new drugs or interference...

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Detalles Bibliográficos
Autores principales: Sun, Yifeng, Fang, Qiongxuan, Liu, Wei, Liu, Yi, Zhang, Chunming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366213/
https://www.ncbi.nlm.nih.gov/pubmed/37488121
http://dx.doi.org/10.1038/s41419-023-05926-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366213/
https://www.ncbi.nlm.nih.gov/pubmed/37488121
http://dx.doi.org/10.1038/s41419-023-05926-6

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