Catalytic mechanism of the zinc-dependent MutL endonuclease reaction

DNA mismatch repair endonuclease MutL binds two zinc ions. However, the endonuclease activity of MutL is drastically enhanced by other divalent metals such as manganese, implying that MutL binds another catalytic metal at some site other than the zinc-binding sites. Here, we solved the crystal struc...

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Detalles Bibliográficos
Autores principales: Fukui, Kenji, Yamamoto, Tatsuya, Murakawa, Takeshi, Baba, Seiki, Kumasaka, Takashi, Yano, Takato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366529/
https://www.ncbi.nlm.nih.gov/pubmed/37487639
http://dx.doi.org/10.26508/lsa.202302001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366529/
https://www.ncbi.nlm.nih.gov/pubmed/37487639
http://dx.doi.org/10.26508/lsa.202302001

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