Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops

Polycomb repressive complex 1 (PRC1) strongly influences 3D genome organization, mediating local chromatin compaction and clustering of target loci. Several PRC1 subunits have the capacity to form biomolecular condensates through liquid–liquid phase separation in vitro and when tagged and over-expre...

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Detalles Bibliográficos
Autores principales: Williamson, Iain, Boyle, Shelagh, Grimes, Graeme R, Friman, Elias T, Bickmore, Wendy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366532/
https://www.ncbi.nlm.nih.gov/pubmed/37487640
http://dx.doi.org/10.26508/lsa.202302101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366532/
https://www.ncbi.nlm.nih.gov/pubmed/37487640
http://dx.doi.org/10.26508/lsa.202302101

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