Cargando…

Traceless Thioacid-Mediated Radical Cyclization of 1,6-Dienes

[Image: see text] Five-membered ring systems are ubiquitous throughout natural products and synthetic therapeutics, and thus, efficient methods to access this essential scaffold are required. Herein, we report the thioacid-mediated, 5-exo-trig cyclization of various 1,6-dienes, with high yields of u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lynch, Dylan M., Nolan, Mark D., Williams, Conor, Van Dalsen, Leendert, Calvert, Susannah H., Dénès, Fabrice, Trujillo, Cristina, Scanlan, Eoin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367065/ https://www.ncbi.nlm.nih.gov/pubmed/37418624 http://dx.doi.org/10.1021/acs.joc.3c00824

Ejemplares similares

Thiyl Radicals: Versatile Reactive Intermediates for Cyclization of Unsaturated Substrates
por: Lynch, Dylan M., et al.
Publicado: (2020)

Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions
por: Zhi, Sanjun, et al.
Publicado: (2023)

A Tripeptide Approach to the Solid‐Phase Synthesis of Peptide Thioacids and N‐Glycopeptides
por: Schöwe, Markus Julian, et al.
Publicado: (2019)

Radical-Mediated Reactions of α-Bromo Aluminium Thioacetals, α-Bromothioesters, and Xanthates for Thiolactone Synthesis
por: McCourt, Ruairí O., et al.
Publicado: (2018)

The direct oxidative diene cyclization and related reactions in natural product synthesis
por: Adrian, Juliane, et al.
Publicado: (2016)

A new method of N to C sequential ligation using thioacid capture ligation and native chemical ligation
por: Hou, Wen, et al.
Publicado: (2018)

Cyclization–endoperoxidation cascade reactions of dienes mediated by a pyrylium photoredox catalyst
por: Gesmundo, Nathan J, et al.
Publicado: (2014)

Asymmetric radical carboesterification of dienes
por: Zhu, Xiaotao, et al.
Publicado: (2021)

Fusing Antigens and Adjuvants into Traceless Nanogels
por: De Geest, Bruno G.
Publicado: (2020)

Traceless Redox-Annulations of Alicyclic Amines
por: Rickertsen, Dillon R. L., et al.
Publicado: (2020)

Self-Terminating, Oxidative Radical Cyclizations
por: Dreessen, Tim, et al.
Publicado: (2004)

Traceless and Site-Specific Ubiquitination of Recombinant Proteins
por: Virdee, Satpal, et al.
Publicado: (2011)

In meso crystallogenesis. Compatibility of the lipid cubic phase with the synthetic digitonin analogue, glyco-diosgenin
por: van Dalsen, Leendert, et al.
Publicado: (2020)

Activation modes in biocatalytic radical cyclization reactions
por: Ye, Yuxuan, et al.
Publicado: (2021)

Releasable and traceless PEGylation of arginine-rich antimicrobial peptides
por: Gong, Y., et al.
Publicado: (2017)

Cyclization vs. Cyclization/Dimerization in o-Amidostilbene Radical Cation Cascade Reactions: The Amide Question
por: Kee, Chin Hui, et al.
Publicado: (2011)

Projectors and seed conformal blocks for traceless mixed-symmetry tensors
por: Costa, Miguel S., et al.
Publicado: (2016)

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells
por: Jiménez‐Moreno, Ester, et al.
Publicado: (2016)

Metal‐Free Aryl Cross‐Coupling Directed by Traceless Linkers
por: Haensch, Veit G., et al.
Publicado: (2019)

Strategic Evaluation of the Traceless Staudinger Ligation for Radiolabeling with the Tricarbonyl Core
por: Mamat, Constantin, et al.
Publicado: (2021)

Traceless enzymatic protein synthesis without ligation sites constraint
por: Li, Ruifeng, et al.
Publicado: (2021)

Traceless Staudinger Ligation to Access Stable Aminoacyl- or Peptidyl-Dinucleotide
por: Kitoun, Camélia, et al.
Publicado: (2023)

Oxidative radical ring-opening/cyclization of cyclopropane derivatives
por: Liu, Yu, et al.
Publicado: (2019)

Exploiting the radical reactivity of diazaphosphinanes in hydrodehalogenations and cascade cyclizations
por: Zhang, Jingjing, et al.
Publicado: (2020)

Metal- and base-free tandem sulfonylation/cyclization of 1,5-dienes with aryldiazonium salts via the insertion of sulfur dioxide
por: Wang, Xiaohong, et al.
Publicado: (2022)

Expeditious synthesis of the fused hexacycle of puberuline C via a radical-based cyclization/translocation/cyclization process
por: Hagiwara, Koichi, et al.
Publicado: (2016)

Traceless Cleavage of Protein–Biotin Conjugates under Biologically Compatible Conditions
por: Cowell, Joseph, et al.
Publicado: (2017)

Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations
por: Wang, Yinglu, et al.
Publicado: (2018)

VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9
por: Montagna, Claudia, et al.
Publicado: (2018)

Traceless Immobilization of Analytes for High-Throughput Experiments with SAMDI Mass Spectrometry
por: Helal, Kazi Y., et al.
Publicado: (2018)

Selective immunocapture and light-controlled traceless release of transiently caged proteins
por: Rakauskaitė, Rasa, et al.
Publicado: (2021)

Traceless cysteine-linchpin enables precision engineering of lysine in native proteins
por: Reddy, Neelesh C., et al.
Publicado: (2022)

Photochemical Aryl Radical Cyclizations to Give (E)-3-Ylideneoxindoles
por: Gurry, Michael, et al.
Publicado: (2014)

Hydroalkynylative cyclization of 1,6-enynes with terminal alkynes
por: Teng, Qi, et al.
Publicado: (2019)

Diastereoselectivity on Intramolecular Alder‐ene Reaction of 1,6‐Dienes
por: de Cózar, Abel
Publicado: (2022)

N(2)H(4) as traceless mediator for homo- and cross- aryl coupling
por: Lv, Leiyang, et al.
Publicado: (2018)

Traceless aptamer-mediated isolation of CD8(+) T cells for CAR-T cell therapy
por: Kacherovsky, Nataly, et al.
Publicado: (2019)

Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells
por: Lee, Miseon, et al.
Publicado: (2020)

A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction
por: He, Maomao, et al.
Publicado: (2020)

N-Aminopyridinium reagents as traceless activating groups in the synthesis of N-Aryl aziridines
por: Tan, Hao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i25dh6h8l5qsgp6f2t3sbdk46a