Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane

[Image: see text] Mol-scale oxyfunctionalization of cyclohexane to cyclohexanol/cyclohexanone (KA-oil) using an unspecific peroxygenase is reported. Using AaeUPO from Agrocybe aegerita and simple H(2)O(2) as an oxidant, cyclohexanol concentrations of more than 300 mM (>60% yield) at attractive pr...

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Autores principales: Hilberath, Thomas, van Oosten, Remco, Victoria, Juliet, Brasselet, Hugo, Alcalde, Miguel, Woodley, John M., Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367066/
https://www.ncbi.nlm.nih.gov/pubmed/37496955
http://dx.doi.org/10.1021/acs.oprd.3c00135
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author Hilberath, Thomas
van Oosten, Remco
Victoria, Juliet
Brasselet, Hugo
Alcalde, Miguel
Woodley, John M.
Hollmann, Frank
author_facet Hilberath, Thomas
van Oosten, Remco
Victoria, Juliet
Brasselet, Hugo
Alcalde, Miguel
Woodley, John M.
Hollmann, Frank
author_sort Hilberath, Thomas
collection PubMed
description [Image: see text] Mol-scale oxyfunctionalization of cyclohexane to cyclohexanol/cyclohexanone (KA-oil) using an unspecific peroxygenase is reported. Using AaeUPO from Agrocybe aegerita and simple H(2)O(2) as an oxidant, cyclohexanol concentrations of more than 300 mM (>60% yield) at attractive productivities (157 mM h(–1), approx. 15 g L(–1) h(–1)) were achieved. Current limitations of the proposed biooxidation system have been identified paving the way for future improvements and implementation.
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spelling pubmed-103670662023-07-26 Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane Hilberath, Thomas van Oosten, Remco Victoria, Juliet Brasselet, Hugo Alcalde, Miguel Woodley, John M. Hollmann, Frank Org Process Res Dev [Image: see text] Mol-scale oxyfunctionalization of cyclohexane to cyclohexanol/cyclohexanone (KA-oil) using an unspecific peroxygenase is reported. Using AaeUPO from Agrocybe aegerita and simple H(2)O(2) as an oxidant, cyclohexanol concentrations of more than 300 mM (>60% yield) at attractive productivities (157 mM h(–1), approx. 15 g L(–1) h(–1)) were achieved. Current limitations of the proposed biooxidation system have been identified paving the way for future improvements and implementation. American Chemical Society 2023-06-09 /pmc/articles/PMC10367066/ /pubmed/37496955 http://dx.doi.org/10.1021/acs.oprd.3c00135 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Hilberath, Thomas
van Oosten, Remco
Victoria, Juliet
Brasselet, Hugo
Alcalde, Miguel
Woodley, John M.
Hollmann, Frank
Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
title Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
title_full Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
title_fullStr Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
title_full_unstemmed Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
title_short Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
title_sort toward kilogram-scale peroxygenase-catalyzed oxyfunctionalization of cyclohexane
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367066/
https://www.ncbi.nlm.nih.gov/pubmed/37496955
http://dx.doi.org/10.1021/acs.oprd.3c00135
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