Stereo-Controlled Liquid Phase Synthesis of Phosphorothioate Oligonucleotides on a Soluble Support

[Image: see text] 5′-O-(2-Methoxyisopropyl) (MIP)-protected 2′-deoxynucleosides as chiral P(V)-building blocks, based on the limonene-derived oxathiaphospholane sulfide, were synthesized and used for the assembly of di-, tri-, and tetranucleotide phosphorothioates on a tetrapodal pentaerythritol-der...

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Detalles Bibliográficos
Autores principales: Rosenqvist, Petja, Saari, Verneri, Pajuniemi, Ella, Gimenez Molina, Alejandro, Ora, Mikko, Horvath, Andras, Virta, Pasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367069/
https://www.ncbi.nlm.nih.gov/pubmed/37428953
http://dx.doi.org/10.1021/acs.joc.3c01006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367069/
https://www.ncbi.nlm.nih.gov/pubmed/37428953
http://dx.doi.org/10.1021/acs.joc.3c01006

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