Cargando…

Stereo-Controlled Liquid Phase Synthesis of Phosphorothioate Oligonucleotides on a Soluble Support

[Image: see text] 5′-O-(2-Methoxyisopropyl) (MIP)-protected 2′-deoxynucleosides as chiral P(V)-building blocks, based on the limonene-derived oxathiaphospholane sulfide, were synthesized and used for the assembly of di-, tri-, and tetranucleotide phosphorothioates on a tetrapodal pentaerythritol-der...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosenqvist, Petja, Saari, Verneri, Pajuniemi, Ella, Gimenez Molina, Alejandro, Ora, Mikko, Horvath, Andras, Virta, Pasi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367069/ https://www.ncbi.nlm.nih.gov/pubmed/37428953 http://dx.doi.org/10.1021/acs.joc.3c01006

Ejemplares similares

Electronic Structures of LNA Phosphorothioate Oligonucleotides
por: Bohr, Henrik G., et al.
Publicado: (2017)

Phosphorothioate modified oligonucleotide–protein interactions
por: Crooke, Stanley T, et al.
Publicado: (2020)

Acetylated and Methylated β-Cyclodextrins as Viable Soluble Supports for the Synthesis of Short 2′-Oligodeoxyribo-nucleotides in Solution
por: Molina, Alejandro Gimenez, et al.
Publicado: (2012)

Selective Covalent Conjugation of Phosphorothioate DNA Oligonucleotides with Streptavidin
por: Rabe, Kersten S., et al.
Publicado: (2011)

Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides
por: Enmark, Martin, et al.
Publicado: (2019)

Oligonucleotide Phosphorothioates Enter Cells by Thiol‐Mediated Uptake
por: Laurent, Quentin, et al.
Publicado: (2021)

Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin
por: Rosenqvist, Petja, et al.
Publicado: (2019)

Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway
por: Artukka, Erika, et al.
Publicado: (2023)

Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks
por: Jabgunde, Amit M, et al.
Publicado: (2015)

Solid-Phase Synthesis of Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides and Their Potential as Antisense Oligonucleotides
por: Takahashi, Yuhei, et al.
Publicado: (2021)

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages
por: Liang, Xue-hai, et al.
Publicado: (2015)

Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides
por: Kostov, Ondřej, et al.
Publicado: (2019)

A Versatile and Convenient Synthesis of (34)S‐Labeled Phosphorothioate Oligonucleotides
por: Stulz, Rouven, et al.
Publicado: (2018)

Oxazinomycin arrests RNA polymerase at the polythymidine sequences
por: Prajapati, Ranjit K, et al.
Publicado: (2019)

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
por: Koller, Erich, et al.
Publicado: (2011)

Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents
por: Enmark, Martin, et al.
Publicado: (2019)

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
por: Genna, Vito, et al.
Publicado: (2023)

Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo
por: Jahns, Hartmut, et al.
Publicado: (2021)

Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity
por: Hosoi, Y, et al.
Publicado: (2002)

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides
por: Bailey, Jeffrey K., et al.
Publicado: (2017)

Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides
por: Wang, Shiyu, et al.
Publicado: (2018)

Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties
por: Miroshnichenko, S. K., et al.
Publicado: (2019)

Developing predictive hybridization models for phosphorothioate oligonucleotides using high-resolution melting
por: Wang, Siyuan S., et al.
Publicado: (2022)

Nucleoside alpha-thiotriphosphates, polymerases and the exonuclease III analysis of oligonucleotides containing phosphorothioate linkages
por: Yang, Zunyi, et al.
Publicado: (2007)

Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo
por: Wang, Mingxing, et al.
Publicado: (2018)

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor
por: Schmidt, Karsten, et al.
Publicado: (2017)

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
por: Baker, Ysobel R., et al.
Publicado: (2022)

TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells
por: Liang, Xue-hai, et al.
Publicado: (2014)

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity
por: Siddiqui, Farid A., et al.
Publicado: (2019)

Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures
por: Shen, Wen, et al.
Publicado: (2014)

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals
por: Seth, Punit P, et al.
Publicado: (2012)

Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile
por: Hegarty, John P, et al.
Publicado: (2016)

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides
por: Østergaard, Michael E, et al.
Publicado: (2020)

Inhomogeneous Diastereomeric Composition of Mongersen Antisense Phosphorothioate Oligonucleotide Preparations and Related Pharmacological Activity Impairment
por: Arrico, Lorenzo, et al.
Publicado: (2022)

Inhibitory Effect of Phosphorothioate Oligonucleotide Complementary to G6PD mRNA on Murine Melanoma
por: Yurchenko, Kseniya A., et al.
Publicado: (2023)

Expanding the Scope of the Cleavable N-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates
por: Aho, Aapo, et al.
Publicado: (2021)

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
por: Wan, W. Brad, et al.
Publicado: (2014)

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity
por: Liang, Xue-Hai, et al.
Publicado: (2016)

2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF
por: Shen, Wen, et al.
Publicado: (2015)

Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides
por: Wang, Shiyu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_uirtl77r5h2bgftv44bqgr3pap