Cargando…

Granzyme-A deficiency attenuates experimental osteoarthritis in mice, but perforin deficiency does not

OBJECTIVES: This study aims to assess the development of osteoarthritis (OA) in granzyme A- (gzmA) and B- (gzmB) and perforin- (perf) knockout mice. MATERIALS AND METHODS: A total of 75 male and female C57BL/6 (eight to nine-week-old) mice were allocated to: gzmA-deficient (gzmA-/-) (11 females, 8 m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Calvo, Jorge, Santiago, Llipsy, Arias, Maykel, Pardo, Julián, Albareda, Jorge, Martínez-Lostao, Luis, García-Alvarez, Felícito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bayçınar Medical Publishing 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367147/ https://www.ncbi.nlm.nih.gov/pubmed/37462629 http://dx.doi.org/10.52312/jdrs.2023.892

Ejemplares similares

The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover
por: Garzón-Tituaña, Marcela, et al.
Publicado: (2020)

Biological relevance of Granzymes A and K during E. coli sepsis
por: Uranga-Murillo, Iratxe, et al.
Publicado: (2021)

Perforin deficiency attenuates collagen-induced arthritis
por: Bauer, Kristin, et al.
Publicado: (2005)

Non-vertebral hydatidosis in bone: Difficulties in management
por: García-Alvarez, Felícito, et al.
Publicado: (2023)

Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan
por: Moreno-Martinez, Laura, et al.
Publicado: (2022)

Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis
por: Garzón-Tituaña, Marcela, et al.
Publicado: (2021)

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes
Publicado: (1991)

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer
por: Chuang, C-H, et al.
Publicado: (2014)

Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells
por: Dufait, Inès, et al.
Publicado: (2019)

Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema
por: Morissette, Mathieu C, et al.
Publicado: (2007)

Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway
por: Woodsworth, Daniel J., et al.
Publicado: (2017)

Decreased tumor surveillance in perforin-deficient mice
Publicado: (1996)

Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway
por: Vermijlen, David, et al.
Publicado: (2004)

Expression of Granulisyn, Perforin and Granzymes in Human Milk over Lactation and in the Case of Maternal Infection
por: Twigger, Alecia-Jane, et al.
Publicado: (2018)

Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb
por: Morales-Kastresana, Aizea, et al.
Publicado: (2013)

Perforin Gene Transfer Into Hematopoietic Stem Cells Improves Immune Dysregulation in Murine Models of Perforin Deficiency
por: Carmo, Marlene, et al.
Publicado: (2015)

Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells
por: Thiery, Jerome, et al.
Publicado: (2011)

Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with Adult T cell Leukemia development
por: Akbarin, Mohammad Mehdi, et al.
Publicado: (2020)

Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway
por: Wang, Huixue, et al.
Publicado: (2020)

Temporal Dynamics of Serum Perforin and Granzyme during the Acute Phase of SARS-CoV-2 Infection
por: Rahman, MD Tazikur, et al.
Publicado: (2023)

Cytotoxicity of CD19-CAR-NK92 cells is primarily mediated via perforin/granzyme pathway
por: Althaus, Jonas, et al.
Publicado: (2023)

Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo
por: Uranga, Santiago, et al.
Publicado: (2016)

Toll-Like Receptors 2 and 4 Cooperate in the Control of the Emerging Pathogen Brucella microti
por: Arias, Maykel A., et al.
Publicado: (2017)

Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis
por: Sutton, Vivien R., et al.
Publicado: (2007)

Gold Nanoparticles and Graphene Oxide Flakes Enhance Cancer Cells’ Phagocytosis through Granzyme-Perforin-Dependent Biomechanism
por: Al-Omar, Mohsen S., et al.
Publicado: (2021)

NADPH oxidase 4 deficiency attenuates experimental osteoarthritis in mice
por: Renaudin, Félix, et al.
Publicado: (2023)

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization
por: Shi, Lianfa, et al.
Publicado: (1997)

Perforin and Granzyme B Have Separate and Distinct Roles during Atherosclerotic Plaque Development in Apolipoprotein E Knockout Mice
por: Hiebert, Paul R., et al.
Publicado: (2013)

Cytomegalovirus (CMV)-Specific Perforin and Granzyme B ELISPOT Assays Detect Reactivation of CMV Infection in Inflammatory Bowel Disease
por: Nowacki, Tobias M., et al.
Publicado: (2012)

Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8 (+) T cells boost cancer cell elimination
por: Zöphel, Dorina, et al.
Publicado: (2022)

Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice
por: Kägi, David, et al.
Publicado: (1997)

Fluorogenic Granzyme A Substrates Enable Real‐Time Imaging of Adaptive Immune Cell Activity
por: Cheng, Zhiming, et al.
Publicado: (2023)

Osteoarthritis associated with estrogen deficiency
por: Roman-Blas, Jorge A, et al.
Publicado: (2009)

Superantigen reactive Vβ6(+) T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells
por: Müerköster, S, et al.
Publicado: (2002)

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
por: Waterhouse, Nigel J., et al.
Publicado: (2006)

Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway
por: Díaz‐Basabe, Angélica, et al.
Publicado: (2021)

Resistance to Granzyme B-mediated Cytochrome c Release in Bak-deficient Cells
por: Wang, Gui-Qiang, et al.
Publicado: (2001)

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
por: Pardo, Julián, et al.
Publicado: (2004)

T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations
por: Ghosh, Sujal, et al.
Publicado: (2018)

PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells
por: Pesini, Cecilia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s3k641rq3nuluciea3p48nr86a