A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein

BACKGROUND: The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential universa...

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Detalles Bibliográficos
Autores principales: Kumar, Ujjwal, Goyal, Priya, Madni, Zaid K., Kamble, Kajal, Gaur, Vineet, Rajala, Maitreyi S., Salunke, Dinakar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367348/
https://www.ncbi.nlm.nih.gov/pubmed/37491224
http://dx.doi.org/10.1186/s12929-023-00950-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367348/
https://www.ncbi.nlm.nih.gov/pubmed/37491224
http://dx.doi.org/10.1186/s12929-023-00950-2

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