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A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein
BACKGROUND: The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential universa...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367348/ https://www.ncbi.nlm.nih.gov/pubmed/37491224 http://dx.doi.org/10.1186/s12929-023-00950-2 |