The role of mitochondrial genes on nuclear gene expression in neovascular age related macular degeneration: analysis of nuclear VEGF gene expression after ranibizumab treatment in cytoplasmic hybrid retinal pigment epithelial cell lines correlated with clinical evolution

PURPOSE: The present study tests the hypothesis that mitochondrial genes have retrograde signaling capacity that influences the expression of nuclear genes related to angiogenesis pathways. Cytoplasmic hybrid (cybrid) in vitro cell lines with patient specific mitochondria inserted into an immortaliz...

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Detalles Bibliográficos
Autores principales: Costa, Rodrigo Donato, Thomaz Neto, Farid José, Moustafa, M. Tarek, Atilano, Shari R., Chwa, Marilyn, Cáceres-del-Carpi, Javier, Mohamed, Mohamed Hamid, Kenney, M. Cristina, Kuppermann, Baruch D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367366/
https://www.ncbi.nlm.nih.gov/pubmed/37491310
http://dx.doi.org/10.1186/s40942-023-00476-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367366/
https://www.ncbi.nlm.nih.gov/pubmed/37491310
http://dx.doi.org/10.1186/s40942-023-00476-7

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