MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism

Colorectal cancer (CRC) driven by PTEN deficiency exhibits high risk of metastasis, advancement of tumor stages and chemotherapy resistance, where no effective therapy has been developed. In this study, we performed a synthetic lethal drug screening in CRC and found that PTEN-deficient CRC cells are...

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Detalles Bibliográficos
Autores principales: Ren, Guowen, Yang, Eun Ju, Tao, Shishi, Mou, Pui Kei, Pu, Yue, Chen, Li-Jie, Shim, Joong Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367566/
https://www.ncbi.nlm.nih.gov/pubmed/37496993
http://dx.doi.org/10.7150/ijbs.82566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367566/
https://www.ncbi.nlm.nih.gov/pubmed/37496993
http://dx.doi.org/10.7150/ijbs.82566

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