Cargando…

Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling

Large tumor suppressor kinase 2 (Lats2) is a member of the Hippo pathway, a critical regulator of organ size. Since Lats2 activity may trigger mitochondrial dysfunction, a key pathogenic factor in acute myocardial infarction (AMI), this study sought to investigate whether Lats2 deletion confers card...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Libao, Huang, Shuai, Du, Yingzhen, Zhou, Hao, Zhang, Kai, He, Jinyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10367568/ https://www.ncbi.nlm.nih.gov/pubmed/37497006 http://dx.doi.org/10.7150/ijbs.84426

Ejemplares similares

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction
por: Bawamia, Bilal, et al.
Publicado: (2023)

Kounis Syndrome: Bee Sting-Induced Acute Myocardial Infarction
por: Borkar, Sonali K, et al.
Publicado: (2023)

LATS2 Deletion Attenuates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Biogenesis
por: Chen, Yi, et al.
Publicado: (2021)

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction
por: Disatnik, Marie‐Hélène, et al.
Publicado: (2013)

Non-ST-elevation myocardial infarction after a wasp sting
por: Gawlik, Radoslaw, et al.
Publicado: (2014)

Allergic myocardial infarction (Kounis syndrome) in a child with scorpion sting
por: Verma, Sudeep, et al.
Publicado: (2021)

Kounis syndrome: Acute myocardial infarction following multiple bee stings
por: Pirasath, Selladurai, et al.
Publicado: (2021)

Retracted: LATS2 Deletion Attenuates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Biogenesis
por: Longevity, Oxidative Medicine and Cellular
Publicado: (2023)

When Venom Meets the Heart: A Rare Case of Scorpion Sting-Induced Acute Myocardial Infarction
por: Koshy, Preethy, et al.
Publicado: (2023)

Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex
por: Tay, Ye Dee, et al.
Publicado: (2019)

Myocardial infarction following a bee sting: A case report of Kounis syndrome
por: Aminiahidashti, Hamed, et al.
Publicado: (2016)

Appropriate Dose of Dapagliflozin Improves Cardiac Outcomes by Normalizing Mitochondrial Fission and Reducing Cardiomyocyte Apoptosis After Acute Myocardial Infarction
por: Fan, Zhong-guo, et al.
Publicado: (2022)

Intraspecific Diversity of Fission Yeast Mitochondrial Genomes
por: Tao, Yu-Tian, et al.
Publicado: (2019)

Participation of mitochondrial fission during mitophagy
por: Mao, Kai, et al.
Publicado: (2013)

Systemic Atherosclerotic Inflammation Following Acute Myocardial Infarction: Myocardial Infarction Begets Myocardial Infarction
por: Joshi, Nikhil V, et al.
Publicado: (2015)

Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction
por: Cai, Shanshan, et al.
Publicado: (2023)

Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission
por: Sun, Xiaoou, et al.
Publicado: (2017)

STING: infection, inflammation and cancer
por: Barber, Glen N.
Publicado: (2015)

STING Signaling and Sterile Inflammation
por: Couillin, Isabelle, et al.
Publicado: (2021)

Mitochondrial fission factor (MFF) frameshift variant in Bullmastiffs with mitochondrial fission encephalopathy
por: Christen, Matthias, et al.
Publicado: (2022)

In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditions
por: Mori, Ayaka, et al.
Publicado: (2023)

Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study
por: Ong, Sang-Bing, et al.
Publicado: (2019)

Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction
por: Luo, Zhi-rong, et al.
Publicado: (2019)

Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway
por: Zhou, Lu, et al.
Publicado: (2021)

Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors
por: Kantipudi, Satish, et al.
Publicado: (2021)

TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein
por: Lu, Yongbin, et al.
Publicado: (2022)

Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction
por: Klose, Aglaia Maria, et al.
Publicado: (2020)

MicroRNA-93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarction
por: Ma, Chengjie, et al.
Publicado: (2020)

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission
por: Shahni, Rojeen, et al.
Publicado: (2015)

Bezafibrate Improves Mitochondrial Fission and Function in DNM1L-Deficient Patient Cells
por: Douiev, Liza, et al.
Publicado: (2020)

Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation
por: Najafi, Maryam, et al.
Publicado: (2016)

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation
por: Ouyang, Weijie, et al.
Publicado: (2023)

Energy metabolism disorder dictates chronic hypoxia damage in heart defect with tetralogy of fallot
por: Liu, Libao, et al.
Publicado: (2023)

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice
por: Du, Lin‐Juan, et al.
Publicado: (2020)

Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan
por: Lefevre, Sophie D, et al.
Publicado: (2015)

Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis
por: Chen, Yuhong, et al.
Publicado: (2023)

Mitochondrial Genome Mutations Associated with Myocardial Infarction
por: Sazonova, Margarita A., et al.
Publicado: (2018)

Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages
por: Alalaiwe, Ahmed, et al.
Publicado: (2021)

Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
por: Zhou, Hao, et al.
Publicado: (2017)

Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia
por: Shi, Wen, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t53f2ibro8pinbs5f4nfthi76s