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NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368268/ https://www.ncbi.nlm.nih.gov/pubmed/37490433 http://dx.doi.org/10.1371/journal.pbio.3002226 |