NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes

Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.

Detalles Bibliográficos
Autor principal: Yao, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368268/
https://www.ncbi.nlm.nih.gov/pubmed/37490433
http://dx.doi.org/10.1371/journal.pbio.3002226
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author Yao, Yao
author_facet Yao, Yao
author_sort Yao, Yao
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description Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
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spelling pubmed-103682682023-07-26 NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes Yao, Yao PLoS Biol Primer Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. Public Library of Science 2023-07-25 /pmc/articles/PMC10368268/ /pubmed/37490433 http://dx.doi.org/10.1371/journal.pbio.3002226 Text en © 2023 Yao Yao https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Yao, Yao
NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
title NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
title_full NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
title_fullStr NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
title_full_unstemmed NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
title_short NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
title_sort nr4a1 destabilizes tnf mrna in microglia and modulates stroke outcomes
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368268/
https://www.ncbi.nlm.nih.gov/pubmed/37490433
http://dx.doi.org/10.1371/journal.pbio.3002226
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