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Leader peptide removal in lasso peptide biosynthesis based on penultimate isoleucine residue

Lasso peptides are ribosomally synthesized peptides that undergo post-translational modifications including leader peptide removal by B (or the segregated B1 and B2) proteins and core peptide macrolactamization by C proteins to form a unique lariat topology. A conserved threonine residue at the penu...

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Detalles Bibliográficos
Autores principales: Duan, Yuwei, Niu, Weijing, Pang, Linlin, Mu, Da-Shuai, Du, Zong-Jun, Zhang, Youming, Bian, Xiaoying, Zhong, Guannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368454/
https://www.ncbi.nlm.nih.gov/pubmed/37497541
http://dx.doi.org/10.3389/fmicb.2023.1181125