Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4(+) CAR T-cell antitumor activity

CD4(+) T cells and CD4(+) chimeric antigen receptor (CAR) T cells display highly variable antitumor activity in preclinical models and in patients; however, the mechanisms dictating how and when CD4(+) T cells promote tumor regression are incompletely understood. With the help of functional intravit...

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Detalles Bibliográficos
Autores principales: Boulch, Morgane, Cazaux, Marine, Cuffel, Alexis, Guerin, Marion V., Garcia, Zacarias, Alonso, Ruby, Lemaître, Fabrice, Beer, Alexander, Corre, Béatrice, Menger, Laurie, Grandjean, Capucine L., Morin, Florence, Thieblemont, Catherine, Caillat-Zucman, Sophie, Bousso, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368531/
https://www.ncbi.nlm.nih.gov/pubmed/37248395
http://dx.doi.org/10.1038/s43018-023-00570-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368531/
https://www.ncbi.nlm.nih.gov/pubmed/37248395
http://dx.doi.org/10.1038/s43018-023-00570-7

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