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Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains

The recent progress in the prediction of protein structures marked a historical milestone. AlphaFold predicted 200 million protein models with an accuracy comparable to experimental methods. Protein structures are widely used to understand evolution and to identify potential drug targets for the tre...

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Detalles Bibliográficos
Autores principales: Medvedev, Kirill E., Schaeffer, R. Dustin, Chen, Kenneth S., Grishin, Nick V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368619/
https://www.ncbi.nlm.nih.gov/pubmed/37491511
http://dx.doi.org/10.1038/s41598-023-39273-5