A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch

Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox homeostasis remains elusive. Here we show that G6PD is phosphorylated at tyrosine 249/322 by the SRC through the f...

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Detalles Bibliográficos
Autores principales: Sun, Yandi, He, Qian, Li, Jingjia, Yang, Ze, Ahmad, Mashaal, Lin, Yindan, Wu, Di, Zheng, Lei, Li, Jiangtao, Wang, Ben, Chen, Chitty, Hu, Yue, Luo, Heng, Luo, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368634/
https://www.ncbi.nlm.nih.gov/pubmed/37491277
http://dx.doi.org/10.1038/s41419-023-05998-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368634/
https://www.ncbi.nlm.nih.gov/pubmed/37491277
http://dx.doi.org/10.1038/s41419-023-05998-4

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