Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation

Heparanase 2 (Hpa2, HPSE2) is a close homolog of heparanase. Hpa2, however, lacks intrinsic heparan sulfate (HS)-degrading activity, the hallmark of heparanase enzymatic activity. Mutations of HPSE2 were identified in patients diagnosed with urofacial syndrome (UFS), a rare genetic disorder that exh...

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Detalles Bibliográficos
Autores principales: Kayal, Yasmin, Barash, Uri, Naroditsky, Inna, Ilan, Neta, Vlodavsky, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368643/
https://www.ncbi.nlm.nih.gov/pubmed/37491420
http://dx.doi.org/10.1038/s41419-023-05990-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368643/
https://www.ncbi.nlm.nih.gov/pubmed/37491420
http://dx.doi.org/10.1038/s41419-023-05990-y

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