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Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation
Heparanase 2 (Hpa2, HPSE2) is a close homolog of heparanase. Hpa2, however, lacks intrinsic heparan sulfate (HS)-degrading activity, the hallmark of heparanase enzymatic activity. Mutations of HPSE2 were identified in patients diagnosed with urofacial syndrome (UFS), a rare genetic disorder that exh...
Autores principales: | Kayal, Yasmin, Barash, Uri, Naroditsky, Inna, Ilan, Neta, Vlodavsky, Israel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368643/ https://www.ncbi.nlm.nih.gov/pubmed/37491420 http://dx.doi.org/10.1038/s41419-023-05990-y |
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