Human acute leukemia uses branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function

Cancer-specific metabolic activities play a crucial role in the pathogenesis of human malignancies. To investigate human acute leukemia–specific metabolic properties, we comprehensively measured the cellular metabolites within the CD34(+) fraction of normal hematopoietic stem progenitor cells (HSPCs...

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Detalles Bibliográficos
Autores principales: Kikushige, Yoshikane, Miyamoto, Toshihiro, Kochi, Yu, Semba, Yuichiro, Ohishi, Maki, Irifune, Hidetoshi, Hatakeyama, Kiwamu, Kunisaki, Yuya, Sugio, Takeshi, Sakoda, Teppei, Miyawaki, Kohta, Kato, Koji, Soga, Tomoyoshi, Akashi, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368855/
https://www.ncbi.nlm.nih.gov/pubmed/36044390
http://dx.doi.org/10.1182/bloodadvances.2022008242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368855/
https://www.ncbi.nlm.nih.gov/pubmed/36044390
http://dx.doi.org/10.1182/bloodadvances.2022008242

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