Acid-sensing ion channel blocker diminazene facilitates proton-induced excitation of afferent nerves in a similar manner that Na(+)/H(+) exchanger blockers do

Tissue acidification causes sustained activation of primary nociceptors, which causes pain. In mammals, acid-sensing ion channels (ASICs) are the primary acid sensors; however, Na(+)/H(+) exchangers (NHEs) and TRPV1 receptors also contribute to tissue acidification sensing. ASICs, NHEs, and TRPV1 re...

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Detalles Bibliográficos
Autores principales: Tkachenko, Yurii, Khmyz, Volodymyr, Buta, Andrii, Isaev, Dmytro, Maximyuk, Oleksandr, Krishtal, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368877/
https://www.ncbi.nlm.nih.gov/pubmed/37502464
http://dx.doi.org/10.3389/fncel.2023.1131661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368877/
https://www.ncbi.nlm.nih.gov/pubmed/37502464
http://dx.doi.org/10.3389/fncel.2023.1131661

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