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DeDoc2 Identifies and Characterizes the Hierarchy and Dynamics of Chromatin TAD‐Like Domains in the Single Cells

Topologically associating domains (TADs) are functional chromatin units with hierarchical structure. However, the existence, prevalence, and dynamics of such hierarchy in single cells remain unexplored. Here, a new generation TAD‐like domain (TLD) detection algorithm, named deDoc2, to decode the hie...

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Detalles Bibliográficos
Autores principales: Li, Angsheng, Zeng, Guangjie, Wang, Haoyu, Li, Xiao, Zhang, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369259/
https://www.ncbi.nlm.nih.gov/pubmed/37162225
http://dx.doi.org/10.1002/advs.202300366