Cargando…
Elevated PDGF‐BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes
Evidence suggests a unique association between bone aging and neurodegenerative/cerebrovascular disorders. However, the mechanisms underlying bone‐brain interplay remain elusive. Here platelet‐derived growth factor‐BB (PDGF‐BB) produced by preosteoclasts in bone is reported to promote age‐associated...
Autores principales: | Liu, Guanqiao, Wang, Jiekang, Wei, Zhiliang, Fang, Ching‐Lien, Shen, Ke, Qian, Cheng, Qi, Cheng, Li, Tong, Gao, Peisong, Wong, Philip C., Lu, Hanzhang, Cao, Xu, Wan, Mei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369301/ https://www.ncbi.nlm.nih.gov/pubmed/37102631 http://dx.doi.org/10.1002/advs.202206938 |
Ejemplares similares
-
Bone-derived PDGF-BB drives brain vascular calcification in male mice
por: Wang, Jiekang, et al.
Publicado: (2023) -
Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
por: Smyth, Leon C. D., et al.
Publicado: (2022) -
PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner
por: Wang, Fangqian, et al.
Publicado: (2023) -
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury
por: Yao, Fei, et al.
Publicado: (2022) -
A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals
por: Zhu, Jia, et al.
Publicado: (2013)