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Effect of Cyproheptadine on Ventilatory Support-free Days in Critically Ill Patients with COVID-19: An Open-label, Randomized Clinical Trial

BACKGROUND: Serotonin is a mediator of pulmonary hypoxic vasoconstriction. Experimental studies have shown that serotonin-mediated pulmonary vasoconstriction can be inhibited by cyproheptadine. The aim of this study is to assess whether treatment with cyproheptadine compared to usual care increases...

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Detalles Bibliográficos
Autores principales: Boniatti, Márcio Manozzo, Nedel, Wagner Luis, Rihl, Marcos Frata, Schwarz, Patricia, Parolo, Edino, Moretti, Miriane Melo Silveira, Lisboa, Thiago Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369312/
https://www.ncbi.nlm.nih.gov/pubmed/37502298
http://dx.doi.org/10.5005/jp-journals-10071-24482