Variation of Tetrahydrofurans in Thyclotides Enhances Oligonucleotide Binding and Cellular Uptake of Peptide Nucleic Acids

[Image: see text] Selective incorporation of conformational constraints into thyclotides can be used to modulate their binding to complementary oligonucleotides, increase polarity, and optimize uptake into HCT116 cells without assistance from moieties known to promote cell uptake. The X-ray structur...

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Detalles Bibliográficos
Autores principales: Zheng, Hongchao, Clausse, Victor, Amarasekara, Harsha, Mazur, Sharlyn J., Botos, Istvan, Appella, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369417/
https://www.ncbi.nlm.nih.gov/pubmed/37502163
http://dx.doi.org/10.1021/jacsau.3c00198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369417/
https://www.ncbi.nlm.nih.gov/pubmed/37502163
http://dx.doi.org/10.1021/jacsau.3c00198

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