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Arginine Residues Modulate the Membrane Interactions of pHLIP Peptides

[Image: see text] Most processes at the water–membrane interface often involve protonation events in proteins or peptides that trigger important biological functions and events. This is the working principle behind the pHLIP peptide technology. A key titrating aspartate (Asp14 in wt) is required to...

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Detalles Bibliográficos
Autores principales: Silva, Tomás F. D., Visca, Hannah, Klumpp, Craig, Andreev, Oleg A., Reshetnyak, Yana K., Machuqueiro, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369490/
https://www.ncbi.nlm.nih.gov/pubmed/37395685
http://dx.doi.org/10.1021/acs.jcim.3c00360