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The UK BiLEVE and Mendelian randomisation: using multivariable instrumental variables to address “damned if you, damned if you don’t” adjustment problems

OBJECTIVE: To explore the use of multivariable instrumental variables to resolve the “damned if you do, damned if you don’t” adjustment problem created for Mendelian randomisation (MR) analysis using the smoking or lung function related phenotypes in the UK Biobank (UKB). RESULT: “damned if you do,...

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Detalles Bibliográficos
Autores principales: Woolf, Benjamin, Gill, Dipender, Sallis, Hannah, Munafò, Marcus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369748/
https://www.ncbi.nlm.nih.gov/pubmed/37491359
http://dx.doi.org/10.1186/s13104-023-06434-8