Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology

Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause congenital cataract. We report the first single-cell multiomic atlas of lens development, leveraging snRNA-seq, snATAC-seq, and CUT&RUN-seq to discover novel mechanisms of cell fate determination and...

Descripción completa

Detalles Bibliográficos
Autores principales: Tangeman, Jared A, Rebull, Sofia M, Grajales-Esquivel, Erika, Weaver, Jacob M, Bendezu-Sayas, Stacy, Robinson, Michael L, Lachke, Salil A, Rio-Tsonis, Katia Del
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369908/
https://www.ncbi.nlm.nih.gov/pubmed/37502967
http://dx.doi.org/10.1101/2023.07.10.548451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369908/
https://www.ncbi.nlm.nih.gov/pubmed/37502967
http://dx.doi.org/10.1101/2023.07.10.548451

Ejemplares similares