Amyloid β accelerates age-related proteome-wide protein insolubility.

Loss of proteostasis is a highly conserved feature of aging across model organisms and typically results in the accumulation of insoluble protein aggregates. Protein insolubility is a central feature of major age-related neurodegenerative diseases including Alzheimer’s Disease (AD), where hundreds o...

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Detalles Bibliográficos
Autores principales: Anderton, Edward, Chamoli, Manish, Bhaumik, Dipa, King, Christina D., Xie, Xueshu, Foulger, Anna, Andersen, Julie K., Schilling, Birgit, Lithgow, Gordon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369951/
https://www.ncbi.nlm.nih.gov/pubmed/37503138
http://dx.doi.org/10.1101/2023.07.13.548937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369951/
https://www.ncbi.nlm.nih.gov/pubmed/37503138
http://dx.doi.org/10.1101/2023.07.13.548937

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