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sciMET-cap: High-throughput single-cell methylation analysis with a reduced sequencing burden

DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust, high-throughput single-cell DNA methylation assays are now possible (sciMET); however, the genome-wide nature of DNA methylation results in a high sequencing...

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Detalles Bibliográficos
Autores principales: Acharya, Sonia N., Nichols, Ruth V., Rylaarsdam, Lauren E., O’Connell, Brendan L., Braun, Theodore P., Adey, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369954/
https://www.ncbi.nlm.nih.gov/pubmed/37502923
http://dx.doi.org/10.1101/2023.07.12.548718