Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis

Aggregation of leukocyte cell-derived chemotaxin 2 (LECT2) causes ALECT2, a systemic amyloidosis that affects the kidney and liver. Homozygosity of the I40V LECT2 mutation is believed to be necessary but not sufficient for the disease. Previous studies established that LECT2 fibrillogenesis is great...

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Detalles Bibliográficos
Autores principales: Ha, Jeung-Hoi, Xu, Yikang, Sekhon, Harsimranjit, Wilkens, Stephan, Ren, Dacheng, Loh, Stewart N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369975/
https://www.ncbi.nlm.nih.gov/pubmed/37503176
http://dx.doi.org/10.1101/2023.07.13.548788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369975/
https://www.ncbi.nlm.nih.gov/pubmed/37503176
http://dx.doi.org/10.1101/2023.07.13.548788

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