Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

Current cancer immunotherapy (e.g., immune checkpoint blockade (ICB)) has only benefited a small subset of patients. Cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) activation holds the potential to improve cancer immunotherapy by eliciting type-I interferon (IFN-I) responses in...

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Detalles Bibliográficos
Autores principales: Zhou, Shurong, Su, Ting, Cheng, Furong, Cole, Janet, Liu, Xiang, Zhang, Bei, Alam, Shaheer, Liu, Jinze, Zhu, Guizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369979/
https://www.ncbi.nlm.nih.gov/pubmed/37502970
http://dx.doi.org/10.1101/2023.07.13.548237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369979/
https://www.ncbi.nlm.nih.gov/pubmed/37502970
http://dx.doi.org/10.1101/2023.07.13.548237

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