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Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

Current cancer immunotherapy (e.g., immune checkpoint blockade (ICB)) has only benefited a small subset of patients. Cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) activation holds the potential to improve cancer immunotherapy by eliciting type-I interferon (IFN-I) responses in...

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Detalles Bibliográficos
Autores principales:	Zhou, Shurong, Su, Ting, Cheng, Furong, Cole, Janet, Liu, Xiang, Zhang, Bei, Alam, Shaheer, Liu, Jinze, Zhu, Guizhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369979/ https://www.ncbi.nlm.nih.gov/pubmed/37502970 http://dx.doi.org/10.1101/2023.07.13.548237

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